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[Chemical Knowledge]：Production method and process flow of ethyl tert-butyl acetophenone

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Manufacturing method
of ethyl tert-butyl acetophenone
Ethyl tert-butyl acetophenone (ETBPA) is an important raw material for chemical production, which is widely used in medicine, pesticide, perfume and other fields. This article will introduce a common ethyl tert-butyl acetophenone manufacturing method.

1. raw materials and equipment

1. raw materials: acetophenone, ethyl magnesium bromide, tert butyl chloride.
2. Equipment: reaction kettle, condenser, separatory funnel, stirrer, thermometer, pH meter, etc.

2. Manufacturing Steps

1. Add appropriate amount of acetophenone and solvent into the reaction kettle and stir well.
2. Ethyl magnesium bromide was prepared in a separate vessel and then slowly added dropwise to the reaction kettle at a controlled rate to maintain the reaction temperature within a suitable range.
3. After the dropwise addition is completed, continue stirring for a period of time to allow the reaction to proceed fully.
4. Slowly add tert-butyl chloride into the reaction kettle, control the dropping rate, and observe the change of reaction temperature and pH value.
5. After the addition is completed, continue to stir for a period of time, and then stand for stratification.
6. The organic layer was separated, washed with water until neutral and then dried over anhydrous sodium sulfate.
7. The solvent is recovered by distillation to obtain a crude product.
8. The crude product can be purified by recrystallization or distillation to obtain pure ethyl tert-butyl acetophenone.

3. precautions

1. The reaction temperature and pH value should be strictly controlled during the operation to avoid the occurrence of side reactions.
2. When adding ethyl magnesium bromide and tert-butyl chloride dropwise, the dropping speed should be controlled to avoid too fast and too violent reaction.
3. In the process of washing and drying, attention should be paid to the operation specifications to avoid product loss and pollution.
4. The appropriate method and conditions should be selected in the refining process to ensure the purity and yield of the product.

4. safety and environmental protection

1. Pay attention to safety during operation, avoid contact with fire and heat sources, and avoid inhaling and eating products.
2. Waste should be properly disposed of to avoid harm to the environment and human body.

In short, the manufacture of ethyl tert-butyl acetophenone requires strict compliance with operating procedures and safety and environmental protection requirements to ensure product quality and yield, while reducing production costs and improving the economic and social benefits of the enterprise.

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