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[Chemical Knowledge]：Propyl isobutyl acetophenone production method and process flow

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Propyl isobutyl acetophenone (PIBPA) is an important organic chemical raw material, widely used in medicine, pesticides, spices and other fields. This paper will introduce a method of manufacturing propyl isobutyl acetophenone, which uses acetophenone and isobutyraldehyde as raw materials, and is prepared through condensation, alkylation and other reaction steps.

1. raw materials and equipment

1 raw materials: acetophenone, isobutyraldehyde, propanol, sulfuric acid, sodium hydroxide, etc.
2. Equipment: reaction kettle, stirrer, condenser, water separator, thermometer, pH meter, etc.

2. Manufacturing Steps

1. Condensation Reaction
Acetophenone and isobutyraldehyde were added into a reactor at a molar ratio of 1:1.2, a small amount of sulfuric acid was added as a catalyst, stirred and heated to 80-90 ° C., and reacted for 6-8 hours. During the reaction, the pH value needs to be checked periodically and adjusted with sodium hydroxide solution to maintain the pH value between 6 and 7. After completion of the reaction, the reaction mixture was cooled to room temperature to precipitate a solid product.

2. alkylation reaction
The solid product obtained by the condensation reaction and propanol are added into a reaction kettle at a molar ratio of 1:1.5, a small amount of sulfuric acid is added as a catalyst, and the mixture is stirred and heated to 120-130 ° C., and reacted for 8-10 hours. During the reaction, the pH value needs to be checked periodically and adjusted with sodium hydroxide solution to maintain the pH value between 6 and 7. After completion of the reaction, the reaction mixture was cooled to room temperature to obtain a crude product of propyl isobutyl acetophenone.

3. Refining
Add the crude product of propyl isobutyl acetophenone into a distillation kettle, heat distillation, and collect the fraction of 150-170°C, which is pure propyl isobutyl acetophenone.

3. precautions

1. In the condensation and alkylation reaction, it is necessary to control the pH value between 6-7 to ensure the smooth progress of the reaction.
2. In the reaction process, it is necessary to regularly detect the temperature and pH value of the reaction solution and adjust the reaction conditions in time.
3. During the distillation process, it is necessary to control the distillation temperature and pressure to ensure the purity and yield of the product.

4. safety and environmental protection

1. In the production process, it is necessary to strictly abide by the safety operation procedures to ensure the safety of employees and equipment.
2. Wastes and by-products need to be treated and used properly to avoid environmental pollution.

In short, the manufacturing method of propyl isobutyl acetophenone introduced in this paper has the advantages of easy access to raw materials, simple operation and high yield, and is suitable for industrial production. At the same time, it is necessary to pay attention to safety and environmental protection in the production process to ensure the quality of products and the sustainable development of the environment.

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