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[Chemical Knowledge]：Production process and preparation method of tert-butyl phenol

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Tert-butyl phenol is a common organic compound, which is often used in medicine, dyes, coatings and other fields, and is also an important intermediate compound. This article will detail the production process and preparation method of tert-butyl phenol.

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1. Advanced production technology
at present, the main production processes of tert-butylphenol include alkylation, hydrogen oxidation and coordination catalysis. Among them, the process of producing tert-butyl phenol by coordination catalysis has become the mainstream.
Coordination catalysis is an effective catalyst to achieve the addition reaction of phenol, and through the improvement of reaction conditions, higher yield and higher selectivity can be obtained. This method can not only realize the efficient preparation of tert-butylphenol, but also has the advantages of low reaction temperature, short reaction time, reduced waste and high product quality.

2. Laboratory preparation method
in the laboratory, tert-butylphenol can be prepared by a variety of methods, one of which is relatively simple and commonly used is by reacting 2-methylphenol with tert-butyl magnesium oxide.
The specific experimental steps are as follows: first, 2-methyl phenol and sodium carbonate powder are mixed and then added to dry methanol to fully dissolve. Then, tert-butyl magnesium oxide was added to the methanol and slowly heated until the reaction was complete. After the reaction, the tert-butyl phenol product was obtained by filtration. The structure of the compound was proved by infrared spectroscopy, nuclear magnetic resonance and other detection methods.

3. Industrial production methods
in industry, the production process and laboratory preparation of tert-butylphenol are different. Coordination catalysis is commonly used to produce large quantities of tert-butylphenol.
The specific implementation step of the coordination catalysis method is that benzyl magnesium halide is added to a system consisting of 2-methylphenol and ruthenium catalyst, and the tert-butyl phenol product is obtained after the reaction. This method has the advantages of low reaction temperature, short reaction time and high yield, and can be industrialized on a large scale.

4. Application of tert-butyl phenol
tert-butyl phenol can be widely used in medicine, dyes, coatings and other industries. Its important application areas are as follows:
(1) the pharmaceutical industry: tert butyl phenol is an important raw material for the preparation of some bioactive drugs, such as analgesics, anticancer drugs, antibacterial drugs, etc.
(2) Dye industry: tert-butyl phenol is a key intermediate for many pigments and dyes, which has the characteristics of enhanced color and stability.
(3) Coating industry: tert-butyl phenol can be used as a stabilizer and antioxidant for coatings, which can greatly improve the service life of coatings.

This article introduces the production process and preparation method of tert-butyl phenol. Tert-butyl phenol is an important chemical substance, which has a wide range of applications in medicine, dyes, coatings and other fields. Coordination catalysis and the reaction of 2-methylphenol with tert-butyl magnesium oxide are the main methods for the preparation of tert-butyl phenol in the laboratory, and coordination catalysis is a common method for the industrial production of tert-butyl phenol.

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