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[Chemical Knowledge]：Notes and methods of sodium methoxide preparation

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Sodium methoxide is a commonly used organic chemical reagent, which is widely used in organic synthesis and laboratory research. Some important matters need to be paid attention to in the preparation of sodium methoxide. The following will introduce the matters needing attention and methods for the preparation of sodium methoxide in detail.

1. Laboratory Safety Precautions
1. Laboratory operators should wear protective glasses, lab clothes and gloves to ensure personal safety.
2. Keep away from open flames and high temperature areas during the preparation process to avoid accidents.
3. Be careful to handle the reagent during operation to avoid damage or pollution caused by splashing or volatilization.

2. Sodium Methoxide Preparation Material Preparation
1. Dry methanol and sodium hydroxide solids need to be prepared.
2. Methanol should be anhydrous and impurity-free and can be purified by distillation.
3. Sodium hydroxide solid should be high purity, avoid containing impurities and moisture.

3. Sodium Methoxide Preparation Step
1. Put dry methanol and sodium hydroxide in a certain molar ratio into a clean glass flask.
2. The mixture in the flask is heated and stirred until the reaction is complete to form sodium methoxide.
3. After cooling, the product is subjected to vacuum distillation or other appropriate methods to obtain pure sodium methoxide solution.

4. precautions
1. the preparation process to control the heating temperature, to avoid excessive high temperature caused by the decomposition of sodium methoxide.
2. Be careful to heat during operation to avoid splashing.
3. After the preparation, the sodium methoxide should be properly stored to avoid moisture and air oxidation.
4. Waste disposal shall comply with laboratory waste disposal regulations to avoid environmental pollution.

5. application of sodium methoxide
1. sodium methoxide can be used for some important reactions in organic synthesis, such as Grignard test, Mannich reaction, etc.
2. Sodium methoxide can also be used for catalytic reduction reactions and synthesis of important heterocyclic compounds.

through the above detailed introduction, I believe we have a deeper understanding of the preparation of sodium methoxide. Only by strictly observing the precautions and operating procedures can the smooth preparation of sodium methoxide and the preparation of high-purity sodium methoxide products be ensured. I hope this article is helpful to you, thank you for reading.