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[Chemical Knowledge]：Precautions and solutions to common problems in acylation experiments

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Acylation is an important organic synthesis reaction, which is widely used in chemistry, pharmacy and other fields. However, in the acylation experiment, often encounter some problems, affect the smooth progress of the experiment. Therefore, it is very important to master the precautions and common problems of acylation experiments to improve the efficiency and success rate of experiments. The following will be from the preparatory work, experimental operation, common problems and solutions in detail.

1. preparation
1. preparation of experimental instruments and equipment: before the acylation experiment, it is necessary to check whether the instruments and equipment in the laboratory are complete to ensure that the experiment will not be affected by insufficient equipment during the experiment.
2. Selection and storage of reagents: Selection of good quality reagents is critical to the success of the experiment. When storing reagents, pay attention to avoid moisture, high temperature, etc., to ensure that the quality of reagents is not affected.
3. safety measures: acylation experiments often use some toxic, volatile reagents, so before the experiment to do adequate safety measures to avoid accidents.

2. experimental operation
1. control of reaction conditions: acylation reaction for temperature, time and other conditions have strict requirements, to ensure that the experiment under the appropriate reaction conditions, to avoid unnecessary problems.
2. Solvent selection and dosage control: Choosing the appropriate solvent and controlling the dosage of the solvent are very important for the success of the acylation experiment.
3. Reaction monitoring and real-time adjustment: During the experiment, the progress of the reaction should be monitored in time, and real-time adjustment and control should be carried out as needed to avoid emergencies.

3. common problems and solutions
1 reaction yield is low: may be due to the experimental conditions are not suitable, the quality of the reagent is not pure and other reasons, can be adjusted by the experimental conditions, the replacement of reagents and other ways to improve the yield.
2. Incomplete reaction: it may be due to insufficient reaction time, inappropriate reaction temperature and other reasons, which can be solved by prolonging the reaction time and increasing the reaction temperature.
3. Product purity is not high: may be due to improper choice of solvent, crystallization conditions are not appropriate and other reasons, can be adjusted by solvent, crystallization conditions and other ways to improve product purity.

summary: acylation experiment is a need for rigorous and meticulous experimental work, only to master the matters needing attention and solutions, in order to better carry out the experimental work. It is hoped that the content described in this paper will be helpful to readers in the acylation experiment, improve the efficiency of the experiment, and successfully complete the experiment.