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[Chemical Knowledge]：The difference and selection principle of preparation dosage form

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Formulation dosage forms refer to various administration forms formed during the production and processing of drugs. Different dosage forms have obvious differences in the route of administration, duration of efficacy, and dissolution rate. Common dosage forms include tablets, capsules, granules, granule-coated agents, pills, sugar-coated tablets, suspensions and the like. So, what are the differences between these formulations? How to choose the appropriate formulation?

First, different formulations have differences in the route of administration. For example, both oral tablets and soft capsules are dosage forms for oral administration, but tablets need to be dissolved and absorbed through the gastrointestinal tract, while soft capsules can be directly absorbed in the gastrointestinal tract. This determines the effect of soft capsules faster, easier to be absorbed, suitable for some drugs that need to take effect quickly. Tablets are more suitable for drugs that require sustained release.

second, there are differences in the dissolution rate of different formulations. For example, granules need to be dissolved in water before they can be absorbed by the body, while the granule coating agent can be swallowed directly, and its coating can protect the drug from being destroyed by gastric acid and release the drug effect in the gastrointestinal tract. This makes the drug effect of the particle coating agent more durable and more stable, and more suitable for some drugs that require a sustained release effect.

Furthermore, the duration of efficacy varies from formulation to formulation. For example, both sugar-coated tablets and suspensions are dosage forms for oral administration, but sugar-coated tablets need to be dissolved in the gastrointestinal tract, and have a long duration of efficacy, which is suitable for drugs that require long-term efficacy. The suspension is dispersed in water, directly absorbed by the body, the efficacy of a short duration, suitable for some drugs that need to take effect quickly.

Therefore, to select the appropriate dosage form, it is necessary to consider the characteristics of the drug itself, the characteristics of the patient and the treatment needs. Generally speaking, for drugs that need quick effect, soft capsules, suspensions and other dosage forms can be selected; while for drugs that need sustained release of drug effect, tablets, granule coating agents and other dosage forms can be selected. In short, when choosing the dosage form of the preparation, we must consider comprehensively according to the specific situation, and choose the most suitable administration form to achieve the best therapeutic effect.

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