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[Chemical Knowledge]：Manufacturing method and process flow of dimethyl malonate

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The manufacturing method
of dimethyl malonate
1. Introduction

dimethyl malonate is an important organic chemical raw material, widely used in medicine, pesticides, spices, dyes and other fields. Therefore, it is of great significance to study the manufacturing method of dimethyl malonate for improving production efficiency, reducing costs and improving product quality. This paper will introduce a manufacturing method of dimethyl malonate, which has the advantages of easy access to raw materials, simple operation and high yield.

2. experimental part of the

1. raw materials and reagents
malonic acid, methanol, sulfuric acid, sodium hydroxide and so on.
2. Experimental equipment
reaction kettle, condenser, water separator, stirrer, etc.
3. Experimental steps
(1) Malonic acid and methanol are added into a reaction kettle at a molar ratio of 1:4, and stirred evenly.
(2) Add an appropriate amount of sulfuric acid as a catalyst, control the reaction temperature at 60-70°C, and react for about 2 hours.
(3) After completion of the reaction, the reaction mixture was cooled to room temperature and neutralized with sodium hydroxide solution to pH 7-8.
(4) The aqueous layer was separated and the organic layer was washed with distilled water until neutral to obtain crude dimethyl malonate.
(5) The crude product is subjected to distillation, and the fraction boiling at 100-102°C is collected to obtain pure dimethyl malonate.

3. Results and Discussion

1. Yield and Purity
In this experiment, the yield of dimethyl malonate reached more than 90% and the purity reached more than 99%.
2. The effect of reaction conditions on the yield
experimental results show that the reaction temperature, the molar ratio of methanol to malonic acid, the amount of catalyst and other factors affect the yield. Under suitable conditions, the yield can be increased to more than 90%.
3. Generation and treatment of by-products
In the reaction process, some by-products will be produced, such as methanol, water and so on. By optimizing the experimental conditions, the formation of by-products can be reduced. At the same time, for the generated by-products, effective treatment methods can also be adopted, such as distillation recovery of methanol, acid-base neutralization treatment, etc.

4. Conclusion

This study introduces a manufacturing method of dimethyl malonate, which has the advantages of easy access to raw materials, simple operation and high yield. Through the optimization of experimental conditions, the yield and purity can be further improved, and the cost can be reduced, which provides a feasible scheme for the production of dimethyl malonate. At the same time, this study also provides a reference for the production of other chemicals.

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