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[Chemical Knowledge]：Manufacturing method and process flow of fumaric acid

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Fumaric acid, also known as fumaric acid, is an important organic chemical raw material, widely used in medicine, pesticides, plastics, rubber and other fields. In the field of chemical production raw materials, the manufacturing methods of fumaric acid mainly include chemical synthesis and biological fermentation.

1. chemical synthesis method

1. maleic anhydride hydrolysis method: this method is maleic anhydride as raw material, under acidic conditions hydrolysis of fumaric acid. The specific operation is that maleic anhydride is mixed with a certain amount of water, sulfuric acid is added as a catalyst, and the reaction is carried out under heating conditions. After completion of the reaction, the fumaric acid product is obtained by cooling crystallization, filtration, drying and the like.

2. Olefin oxidation method: This method uses olefins (such as ethylene, propylene, etc.) as raw materials to produce fumaric acid through oxidation reaction. The specific operation is that the olefin is mixed with oxygen, the catalyst is added, and the reaction is carried out under the condition of high temperature and high pressure. After completion of the reaction, fumaric acid product was obtained through the steps of cooling, separation and purification.

2. biological fermentation method

biological fermentation method is the use of microbial fermentation production of fumaric acid. The specific operation is to mix glucose, corn steep liquor and other nutrients with appropriate amount of water, inoculate fumaric acid producing bacteria, and ferment under suitable temperature, pH value and other conditions. After the fermentation, the fumaric acid product was obtained by centrifugation, filtration and other steps.

compared with chemical synthesis method, biological fermentation method has the advantages of mild conditions, simple operation and low cost, but the current biological fermentation method of acid production and conversion rate is relatively low, still need further research and improvement.

No matter which method is used to manufacture fumaric acid, it is necessary to strictly control the reaction conditions to ensure product quality and production safety. At the same time, factors such as environmental protection and sustainable development need to be considered in the production process to promote the development of chemical production in a green, efficient and sustainable direction.

In short, the manufacturing methods of fumaric acid mainly include chemical synthesis and biological fermentation. Different methods have their own advantages and disadvantages, and suitable methods should be selected according to specific production conditions and needs. In the future development, with the continuous progress and application of technology, the manufacturing method of fumaric acid will be more perfect and optimized, and make greater contributions to the development of chemical production field.

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