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[Chemical Knowledge]：Manufacturing method and process of glycine

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Manufacturing Method
of Glycine
1. Introduction

Glycine is an important chemical production raw material, widely used in medicine, food, agriculture and other fields. Therefore, it is of great significance to study the manufacturing method of glycine for improving production efficiency, reducing cost and improving product purity. This article will introduce the manufacturing methods of glycine, including ammonium chloride method, Stracker method and Heine method.

2. ammonium chloride method

ammonium chloride method is one of the main methods of glycine production, the principle is under alkaline conditions, the reaction of ammonium chloride and hulotropine to generate glycine salt, and then hydrochloric acid acidification to obtain glycine. The specific operation steps are as follows:

1. prepare an alkaline solution of urotropine and sodium hydroxide, add ammonium chloride, add carbon dioxide gas under stirring, control the reaction temperature at 50-60 ° C., and react to generate glycinate.
2. The reaction solution was filtered to remove impurities such as unreacted urotropine and sodium chloride to obtain a glycine salt solution.
3. Acidify the glycine salt solution with hydrochloric acid and control the pH value at 2-3 to precipitate glycine.
4. The precipitated glycine is filtered, washed and dried to obtain a finished product. The advantages of

ammonium chloride method are easy to obtain raw materials, simple operation and low cost. However, a large amount of waste gas and waste water will be produced in the production process of this method, which will cause great pollution to the environment.

3. Schreck method

Schreck method is an improved ammonium chloride method, the principle is on the basis of ammonium chloride method, adding formaldehyde and sodium cyanide, so that the reaction more fully, improve the yield and purity of glycine. The specific operation steps are as follows:

1. prepare an alkaline solution of urotropine, sodium hydroxide and formaldehyde, add ammonium chloride and sodium cyanide, introduce carbon dioxide gas under stirring, control the reaction temperature at 60-70 ℃, and react to generate glycine salt.
2. The reaction solution was filtered to remove impurities such as unreacted urotropine and sodium chloride to obtain a glycine salt solution.
3. Acidify the glycine salt solution with hydrochloric acid and control the pH value at 2-3 to precipitate glycine.
4. The precipitated glycine is filtered, washed and dried to obtain a finished product. The advantage of the

Swindler method is that it improves the yield and purity of glycine and reduces the discharge of waste gas and waste water. However, this method uses toxic raw materials such as sodium cyanide, which poses certain risks to the health of operators and environmental safety.

4. hydantoin method

hydantoin method is a new type of glycine production method, its principle is by 5-hydroxymethyl hydantoin hydrolysis under acidic conditions, the generation of glycine and formaldehyde. The specific operation steps are as follows:

1. prepare an acidic solution of 5-hydroxymethyl hydantoin and sulfuric acid, heat it to 80-90 ℃, and react to generate glycine and formaldehyde.
2. The reaction solution was cooled to room temperature, and sodium hydroxide solution was added to adjust the pH value to neutral to precipitate glycine.
3. The precipitated glycine is filtered, washed and dried to obtain a finished product. The advantages of

hydantoin method are mild reaction conditions, simple operation and high product purity. At the same time, the method avoids the use of toxic raw materials, and is more friendly to the health of operators and the safety of the environment.

5. Conclusion

In summary, ammonium chloride method, Stracker method and Hein method are common glycine manufacturing methods. Different methods have their own advantages and disadvantages, and choosing the appropriate manufacturing method needs to be considered comprehensively according to the specific situation. In the future, with the continuous improvement of environmental awareness and technological progress, more environmentally friendly, efficient and safe glycine manufacturing methods will be more widely used.

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