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[Chemical Knowledge]：Production process and preparation method of isopropyl ether

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Isopropyl ether is a common surgical anesthetic and is widely used in various surgical procedures. The purpose of this paper is to explore the production process and preparation method of isopropyl ether.

Part I: Overview of Isopropyl Ether

Isopropyl Ether, also known as Propropyl Ether Isopropyl Ether, is a surgical anesthetic drug that belongs to ether compounds. It was first prepared in 1915, but we still use this important surgical anesthetic today.

isopropyl ether is mainly used in the operation process, can be used as inducer, maintain anesthesia and postoperative pain analgesia. It can effectively reduce the recovery time after surgery by quickly inducing the anesthesia state, and at the same time can quickly restore the awake state after stopping the infusion.

However, because isopropyl ether has certain side effects, including respiratory depression, decreased heart rate, hypotension, etc., and may be related to liver toxicity, it can only be used under the supervision of a professional doctor.

Part II: Production Process
of Isopropyl Ether The production process of
isopropyl ether mainly includes four steps, namely:

1. Preparation of acetone: The heating reaction of isopropanol and copper oxide catalyst produces acetone.

2 Preparation of acetone sodium hydrofluoride: Acetone sodium hydrofluoride can be obtained by reacting acetone with sodium hydrofluoride.

3. preparation of isopropyl ether: acetone sodium hydrofluoride is reacted with ethanol, and isopropyl ether can be obtained by distillation.

4. Refined isopropyl ether: the use of separation and purification technology, so that the purity of isopropyl ether to pharmaceutical grade.

Part III: Preparation Method of Isopropyl Ether

There are many preparation methods of isopropyl ether, two of which are more common are described below.

method 1:

1. isopropyl alcohol and copper oxide catalyst heating reaction, acetone.

2. Acetone is vaporized and sodium chloride is added to the reactor to continue the reaction to form acetone hydrochloride.

3. Acetone hydrochloride is added to the reactor and reacted with ethanol to produce isopropyl ether.

4. Refined isopropyl ether to make it up to pharmaceutical grade.

method two:

1. isopropyl alcohol and sodium hydroxide solution reaction, generate sodium propoxide.

2. Chloroform is added to sodium propoxide to give 2-acetonyl-1-chloroalkane by distillation.

3. Reaction of 2-acetonyl-1-chloroalkane with sodium hydroxide solution to give isopropyl ether.

4. Refined isopropyl ether to make it up to pharmaceutical grade.