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[Chemical Knowledge]：Production process and preparation method of anisole

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Anisole is a very important industrial raw material, widely used in the production of various types of chemical products. Its production process and preparation method are extremely important in the chemical industry, and the following article will detail the production process and preparation method of anisole.

Structure and properties of 1. anisole
anisole is an organic compound with the chemical formula C8H10O and a molecular weight of 122.17g/mol. It is a colorless transparent liquid, at room temperature can be miscible in ethanol, ether, benzene and tetrahydrofuran and other solvents. Anisole is an important solvent and intermediate, which is widely used in chemical industry, medicine and fragrance.

Production process and preparation method of 2. anisole
the commonly used production processes of anisole mainly include phosphorous anhydride method, methanol method and phenol method.
Phosphite anhydride method: the production of anisole is based on the esterification reaction of phosphite anhydride and benzyl alcohol, and the formation of anisole under the action of a catalyst. The raw materials of the esterification reaction are phosphite anhydride and benzyl alcohol, which are esterified in the presence of sulfuric acid or phosphoric acid, and then reacted to form anisole under the action of a catalyst. The phosphite anhydride method is a very widely used anisole production process at present, its equipment is simple, waste gas treatment is relatively easy, but the use of catalyst is more, there is environmental pressure.
Methanol method: The production of anisole is based on the esterification reaction of benzyl alcohol with methanol, and produces anisole under the action of a catalyst. The raw materials of the esterification reaction are methanol and benzyl alcohol. Under the action of the catalyst, the two react to form tolyl ester (formyl benzene) and water. The toluene ester is then deformylated to give anisole. Although the methanol method has low cost, the catalyst consumption is large and the wastewater treatment is difficult, so it is gradually replaced by the phosphite anhydride method.
Phenol method: The production of anisole is based on the polycondensation reaction of phenol and methanol, and the formation of anisole in the presence of a catalyst. The raw materials of the polycondensation reaction are phenol and methanol. Under the action of the catalyst, the two undergo polycondensation reaction to generate methyl phenol, and then react with methanol again to generate anisole. Phenol method is a chemical production process with complex chemical reactions, which requires high equipment, but less waste water is discharged in the production process and less pollution to the environment.

Precautions for 3. Anisole Production
(1) the reactor equipment requirements are high. The phosphite anhydride method requires a diversion layer of about 30cm at the bottom of the reactor, and at the same time, secondary feeding is required to prevent the accumulation of catalyst in the esterification reaction from hindering the reaction; the methanol method and the phenol method do not require much at the bottom of the reactor, but also need to prevent the accumulation of catalyst.
(2) the choice of catalyst. Catalyst is a key factor in the production of anisole, and different catalysts have an impact on the reaction rate, product yield and wastewater treatment.
(3) Wastewater treatment. In the production of anisole, the waste water contains anisole, benzyl alcohol and other organic and phosphoric acid, sulfuric acid and other inorganic substances. Therefore, the wastewater must be treated to meet the national environmental protection requirements.
(4) Process safety. Anisole is a flammable and explosive organic compound. During the production process, it is necessary to strictly abide by the operating procedures and pay attention to fire prevention and explosion.
In general, the production process and preparation method of anisole is very important, and different processes and methods have their advantages and disadvantages. Before selecting the appropriate process and method plan, it is necessary to conduct careful research and demonstration to ensure the safety, stability and efficiency of the production process.

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