[Chemical Knowledge]：Properties, uses, upstream and downstream raw materials, storage methods of quinoline, harmfulness of quinoline

Quinoline Properties

Quinoline (Quinoline) is an important organic compound, chemical formula is C9H7N, which belongs to nitrogen-containing heterocyclic compounds. It presents a light yellow to light brown liquid state with a special smell. The melting point of quinoline is -15 ℃, the boiling point is 237 ℃, and it is stable at room temperature. Its solubility in water is low, but it is easily soluble in most organic solvents, such as ethanol, ether, benzene, etc. Quinoline molecule has a conjugated π electron system, so it has high chemical reactivity and can participate in a variety of chemical reactions, such as halogenation, nitration, sulfonation and so on.

Quinoline use

As an important chemical raw material and intermediate, quinoline is widely used. In the field of medicine, quinoline and its derivatives are used to synthesize antimalarial drugs, such as chloroquine and quinine; in the dye industry, quinoline can be used to synthesize dyes and chromogenic agents; in pesticides, quinoline is used to make pesticides and herbicides. Quinoline is also used as a catalyst and solvent in organic synthesis and is widely used in the production of resins, rubbers and plastics.

Quinoline upstream and downstream raw materials

Upstream raw materials

The production of quinoline usually uses coal tar as raw material. Coal tar is a complex mixture containing a variety of aromatic compounds, which can be extracted by distillation and separation. In modern industrial production, quinoline can also be prepared by the reaction of aniline and glycerol. Cyclization of aniline and glycerol under acidic conditions produces quinoline and its homologs. Quinoline can also be prepared by the reaction of toluene and methylamine at high temperature and pressure.

Downstream Products

Quinoline has a wide range of downstream products, including various compounds in the fields of medicine, dyes, pesticides, etc. In the field of medicine, quinoline is an important intermediate for the synthesis of antimalarial drugs, such as chloroquine and quinine; in the dye industry, it is used to produce quinoline yellow, quinoline blue and other dyes; in the field of pesticides, quinoline is used to synthesize quinoline insecticides and herbicides. Quinoline is also used as a modifier for synthetic plastics, resins and other polymer materials.

QUINOLINE STORAGE METHOD

Quinoline has certain toxicity and corrosiveness, and corresponding safety measures should be taken during storage and transportation. Quinoline should be stored in a cool, dry, well-ventilated warehouse, away from fire and heat sources, and avoid direct sunlight. Storage containers shall be special containers with good tightness, such as steel or glass lined tanks, to prevent leakage and volatilization. Quinoline is flammable, so the warehouse should be equipped with fire prevention facilities and fire fighting equipment, strictly prohibit smoking and open fire operations. Operators should wear protective gloves, goggles and protective clothing to avoid skin and eye contact when contacting quinoline.

QUINOLINE SAFETY

Quinoline is highly toxic and can enter the human body through the respiratory tract, digestive tract and skin, which is harmful to human health. Long-term exposure to quinoline may cause headache, nausea, vomiting, skin irritation and other symptoms, and may cause liver and kidney damage in severe cases. Quinoline is considered to be carcinogenic, so strict protective measures should be taken during production and use to avoid long-term exposure. The treatment of quinoline waste also needs to follow environmental regulations to avoid environmental pollution.

Quinoline Market Prospects

With the development of downstream industries such as pharmaceuticals, dyes and pesticides, the market demand for quinoline is increasing. Especially in the development of new antimalarial drugs and high-performance dyes, the demand for quinoline as a key intermediate will continue to grow. The application of quinoline in organic synthesis is also expanding, and new application fields and market prospects are broad. The production and use of quinoline is also facing the challenge of environmental protection and safety management. How to improve production efficiency and reduce costs under the premise of ensuring safety and environmental protection is an important issue for the development of quinoline industry in the future.

Conclusion

As an important organic compound, quinoline has a wide range of applications. Its special chemical properties make it play an important role in medicine, dyes, pesticides and other fields. The toxicity and environmental hazards of quinoline also need attention. In the future development, the quinoline industry needs to make continuous efforts in technological innovation, environmental protection and safety management to meet market demand and achieve sustainable development.