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Chloroisopropyleneacetone (Chloroacetone), chemical formula C3H5ClO, is a colorless to light yellow liquid with a pungent odor. It has a molecular weight of 92.52g/mol, a melting point of -87°C, a boiling point of 119°C and a density of about 1.11g/cm³. Chloroisopropyleneacetone has limited solubility in water, but is soluble in most organic solvents such as ethanol, ether and chloroform. The chlorine atom and carbonyl group (C = O) in its chemical structure make it have high chemical activity and can react with a variety of chemical reagents to form a variety of derivatives.
Chloroisopropyleneacetone has a wide range of uses in the chemical and pharmaceutical fields. Its main uses include:
Organic synthesis intermediates: As an important intermediate in organic synthesis, chloroisopropyleneacetone is used in the synthesis of a variety of pharmaceuticals, pesticides and dyes and other chemical products. For example, it can be used in the synthesis of key intermediates for antibiotics, analgesics and other drugs.
Crosslinking agent: In polymer chemistry, chloroisopropyleneacetone can be used as a crosslinking agent to modify the properties of the polymer and improve its thermal stability and mechanical strength.
Solvent: Due to its better solubility, chloroisopropyleneacetone can be used as a solvent for some chemical reactions, especially reactions that require non-polar solvents.
The production of chloroisopropyleneacetone mainly depends on the following upstream raw materials:
Acetone: As the main raw material for the production of chloroisopropyleneacetone, acetone is chlorinated to produce chloroacetone.
Chlorine gas: During the reaction, chlorine gas reacts with acetone to form chloroisopropyleneacetone.
Catalyst: such as sulfuric acid, aluminum chloride and other catalysts in the reaction to accelerate the reaction rate and improve the role of product selectivity.
The downstream products of chloroisopropyleneacetone mainly include:
Drug intermediates: through further chemical reactions, chloroisopropyleneacetone can be converted into a variety of drug intermediates, and then synthesized antibacterial drugs, antiviral drugs and so on.
Pesticides: In the synthesis of some pesticides such as herbicides and insecticides, chloroisopropyleneacetone plays an important role as an intermediate.
Dyes: The synthesis of some dyes requires chloroisopropyleneacetone as the initial raw material to prepare the final dye product through a complex organic synthesis route.
Chloroisoacetone has high reactivity and volatility. Special attention should be paid to the following points during storage:
Sealed containers: Chloroisoacetone should be stored in sealed glass or stainless steel containers to prevent leakage and volatilization.
Avoidance of light: due to the chlorinated isoacetone sensitive to light, storage need to avoid direct sunlight, it is recommended to place in a cool, dry place.
Keep away from fire sources: Chlorinated isoacetone is flammable, and the storage environment should be away from open flames and high temperature areas to avoid volatilization and combustion caused by high temperature.
Good ventilation: storage of chlorinated isoacetone warehouse to maintain good ventilation conditions, to prevent the accumulation of volatiles in the air, causing safety hazards.
Chloroisoacetone is toxic and irritant, and safety regulations must be strictly followed during handling and storage. Personnel should wear appropriate personal protective equipment, such as protective gloves, goggles and respiratory protection. Emergency treatment measures include the immediate evacuation of personnel in the event of a leak and treatment with adsorbents such as activated carbon or dry sand.
Because chlorinated isoacetone has potential harm to the environment, its waste treatment should be carried out in accordance with environmental protection regulations to avoid direct discharge into water and soil to prevent pollution to the ecological environment.
With the continuous development of the chemical and pharmaceutical industries, the demand for chloroisoacetone is gradually increasing. Especially in the field of new drug research and development and high-performance materials development, chloroisoacetone is an important intermediate, and its market demand is expected to continue to grow. The progress of green chemistry and environmental protection technology will also promote the continuous improvement of the production process of chloroisoacetone to reduce its impact on the environment.
As an important chemical intermediate, chloroisoacetone has broad application prospects in many fields. Its production and use process requires strict compliance with safety and environmental protection requirements to ensure that its impact on humans and the environment is minimized. With the continuous advancement of technology and the increase of market demand, the application range of chloroisoacetone will be further expanded to promote the development of related industries.
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