[Chemical Knowledge]：Properties, uses, upstream and downstream raw materials, storage methods, chemical properties of tert-butyl benzene

Properties of tert-butylpropiophenone

tert-butylpropiophenone (tert-Butylphenyl ketone,CAS number: 769-83-5), the molecular formula is C12H16O and the molecular weight is 176.25g/mol. It is an aromatic ketone with the following chemical properties: colorless or pale yellow liquid, boiling point 243-245°C, flash point 101°C, insoluble in water, but soluble in organic solvents such as ethanol, ether, chloroform, etc. Because of its molecular structure contains t-butyl and ketone groups, it is endowed with specific chemical activity and can carry out a variety of chemical reactions, such as esterification, reduction, hydrogenation and so on.

Use of tert-butyl propiophenone

tert-butylpropiophenone has a wide range of applications in the field of organic synthesis, including:

1. pharmaceutical intermediates: As a key intermediate in the synthesis of many drugs, especially in anti-inflammatory drugs, analgesics, etc. It can be used in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, etc.

2. pesticide intermediate in the synthesis of pesticides, tert-butylpropiophenone is also an important intermediate for the synthesis of pesticides, herbicides, etc.

3. Spices and flavors its unique aromatic smell makes it an important raw material in the perfume industry, especially in the manufacture of perfumes and flavors.

4. organic synthesis reagent as a common reagent in organic synthesis, it can be used as the starting material or intermediate product of various chemical reactions, such as Grignard reaction, Friedel-Crafts alkylation, etc.

Upstream and downstream raw materials of tert-butylpropiophenone

upstream raw materials

the production of tert-butylpropiophenone usually requires the following upstream raw materials:

1. phenylacetone: As a basic raw material, phenylacetone is more common in organic synthesis and can be obtained by the Friedel-Crafts reaction of acetophenone and propylene.

2. tert-Butylating reagent commonly used tert-butylation reagents include tert-butyl chloride (t-Butyl chloride) and tert-butyl bromide (t-Butyl bromide), which can be alkylated with phenylacetone in the presence of an acidic catalyst.

3. acid catalyst such as aluminum chloride (AlCl3), used to promote the Friedel-Crafts reaction, improve the reaction efficiency and selectivity.

Downstream Products

1. drugs: Through further chemical modification and reaction, it can be transformed into various pharmaceutical ingredients, especially in the production of anti-inflammatory, analgesic and antibacterial drugs.

2. Pesticides: As an intermediate, it can synthesize a variety of effective pesticides and herbicides, which are widely used in agricultural production.

3. Fine Chemicals: Used in the production of various fine chemicals, such as high-grade spices, special solvents and additives.

Production Process of Tert-Butyl Acetophenone

the production of tert-butyl benzene acetone generally uses Friedel-Crafts alkylation reaction, the specific steps are as follows:

1. preparation of reaction raw materials: Mix phenylacetone and tert-butyl reagent in a certain ratio.
2. Control of reaction conditions: Add an acidic catalyst (such as aluminum chloride) to the reaction kettle, and control the reaction temperature between 40-60°C.
3. Reaction carried out the mixture is alkylated under the action of a catalyst to produce tert-butyl propiophenone.
4. product separation and purification: After the reaction is over, pure tert-butylpropiophenone is isolated by distillation and crystallization.

Storage method of tert-butylpropiophenone

due to the flammability and certain chemical activity of tert-butylpropiophenone, its storage requires special attention:

1. storage Environment: It should be stored in a cool, well-ventilated warehouse, avoid direct sunlight and high temperature environment to prevent decomposition or reaction.

2. Container Requirements use a closed stainless steel or glass container to avoid contact with moisture in the air to prevent hydrolysis or other side reactions.

3. Safety measures the warehouse shall be equipped with corresponding fire extinguishing equipment, such as dry powder fire extinguisher, carbon dioxide fire extinguisher, etc., and equipped with emergency eye washer and flushing equipment.

4. Label and Identification: The storage container should be clearly labeled with the chemical name, purity, production date and safety warning signs to ensure that the operator can correctly identify and handle it.

Market Prospect of Tert-Butylpropiophenone

with the continuous development of pharmaceutical and pesticide industry, the demand for efficient intermediates is increasing year by year. As an important organic synthesis intermediate, the market demand for tert-butylpropiophenone is on the rise. With the progress of organic chemistry technology and the improvement of production process, the production cost of tert-butylpropiophenone will be gradually reduced, and its market competitiveness will be further enhanced. With the rise of green chemistry, more environmentally friendly catalysts and green synthesis routes may be used in the production process in the future, which will have a positive impact on the production and application of tert-butylpropiophenone.

Summary

as an important intermediate in organic synthesis, tert-butylpropiophenone has a wide range of applications. Its unique chemical properties and diverse uses make it play an important role in the fields of medicine, pesticides, spices and fine chemicals. With the continuous optimization of the production process and the increase of market demand, the market prospect of tert-butylpropiophenone will be broader. Through reasonable storage and security management, it can ensure its high efficiency, safety and stability in industrial applications. In the future, with the deepening of the concept of green chemistry and sustainable development, the production and application of Tbutylpropiophenone will usher in more opportunities and challenges.