[Chemical Knowledge]：Properties, uses, upstream and downstream raw materials, storage methods of isobutyryl chloride, price of isobutyryl chloride

Properties of isobutyryl chloride

Isobutyryl chloride (Isobutyryl chloride), chemical formula C4H7ClO, is an organic compound. Appearance is a colorless to pale yellow liquid with a pungent odor. It has a molecular weight of 106.55g/mol, a boiling point of 92-94°C and a density of about 0.994 g/mL. Insoluble in water, but miscible with many organic solvents such as ether, chloroform and benzene. Isobutyryl chloride is highly reactive, especially when it comes into contact with water and alcohols, it will undergo a rapid hydrolysis reaction to generate isobutyric acid and hydrogen chloride. Therefore, its handling and storage require special care to avoid contact with moisture.

Isobutyryl chloride use

Isobutyryl chloride has a wide range of uses in the chemical industry, mainly for the following aspects:

1. Pharmaceutical intermediates: Isobutyryl chloride is an important intermediate in the synthesis of a variety of drugs. In pharmaceutical synthesis, it is often used in acylation reactions to produce isobutyryl derivatives. These derivatives have applications in antibiotics, anticancer drugs and anti-inflammatory drugs.

2. Pesticide intermediates are also key intermediates in the production of certain pesticides. For example, the synthesis of some herbicides and pesticides requires the use of isobutyryl chloride to introduce specific acyl structures to enhance their activity and stability.

3. Organic synthesis: Isobutyryl chloride is used as an acylating reagent in organic synthesis and is widely used in acylation reactions to prepare compounds such as amides, esters, and ketones. It is also used as an intermediate in the manufacture of perfumes and dyes.

Isobutyryl chloride upstream and downstream raw materials

Upstream raw materials

1. Isobutyric acid: The main upstream raw material of isobutyryl chloride is isobutyric acid (Isobutyric acid), the chemical formula of which is C4H8O2. Isobutyric acid can be prepared by oxidation of isobutylene or by oxidation of isobutyraldehyde. Isobutyric acid reacts with a chlorinating agent such as thionyl chloride or phosphorus pentachloride to produce isobutyryl chloride and by-product hydrogen chloride.

2. Chlorinating agents: Commonly used chlorinating agents include thionyl chloride (SOCl2) and phosphorus pentachloride (PCl5). These chlorinating agents react with isobutyric acid to form isobutyryl chloride. Thionyl chloride and phosphorus pentachloride are common in the chemical raw material market, and their production cost and supply stability directly affect the production cost of isobutyryl chloride.

Downstream Products

1. PHARMACEUTICAL COMPOUNDS As mentioned previously, isobutyryl chloride is used in the synthesis of a variety of drugs, especially those containing an isobutyryl structure. The demand for these drugs directly affects the market demand for isobutyryl chloride.

2. Pesticide products: Isobutyryl chloride is also widely used in pesticide synthesis. As the demand of the pesticide market changes, the demand for isobutyryl chloride will fluctuate accordingly.

3. Industrial Chemicals: Isobutyryl chloride is also required for the production of some specialty chemicals, such as specialty esters and amides, which are mainly used in coatings, adhesives and polymers.

Isobutyryl chloride storage method

Due to the high reactivity and sensitivity to moisture of isobutyryl chloride, its storage requires special attention to the following points:

1. Sealed storage: Isobutyryl chloride should be stored in a sealed container to prevent it from contacting moisture in the air. Glass, Teflon or stainless steel containers are usually used.

2. Cool and dry environment: The storage environment should be kept cool and dry, avoiding direct sunlight and high temperature. The storage temperature of the recommend is 10-25°C. High temperature will accelerate its decomposition, and humid environment will cause hydrolysis reaction.

3. Avoid flammables: Isobutyryl chloride is flammable and corrosive. Keep away from flammables and oxidants to avoid fire or explosion due to accidental contact.

4. Good ventilation: The storage area should be well ventilated to prevent the accumulation of isobutyryl chloride vapor. Its vapors are irritating to the respiratory system and long-term exposure may pose a health hazard.

5. Emergency measures: the storage area should be equipped with emergency treatment equipment, such as protective gloves, protective glasses, emergency shower and eye washing equipment. Neutralizers (e. g. lye) should also be prepared to deal with spills.

Conclusion

Isobutyryl chloride, as an important organic synthesis intermediate, is widely used in medicine, pesticide and chemical industry. Its main upstream raw materials are isobutyric acid and chlorinating agents, while downstream products include various pharmaceutical compounds and pesticides. Due to its high reactivity and sensitivity to moisture, the storage and handling of isobutyryl chloride requires special attention to ensure safe and stable use. Understanding its nature, use and storage methods is of great significance to the production and management of chemical enterprises.