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[Chemical Knowledge]：Detection method and analysis technology of mannitol

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The importance of mannitol and its detection method

Mannitol, also known as sorbitol, is a kind of polyol that widely exists in nature. It has a sweet taste and is widely used in food, medicine, cosmetics and other fields. Because of its similarity to glucose, mannitol is used medically as an alternative sweetener for diabetics and also as a sweetener for the manufacture of foods such as chewing gum and candy.

Although mannitol is widely used in various fields, its excessive intake may cause gastrointestinal discomfort and even have adverse effects on diabetic patients. Therefore, the accurate detection of mannitol has become an important issue in food, medicine and other industries.

At present, the commonly used mannitol detection methods include high performance liquid chromatography (HPLC), gas chromatography (GC), infrared spectroscopy (IR), mass spectrometry (MS) and so on. These methods have their own characteristics, and can choose the appropriate method for detection according to different needs.

High performance liquid chromatography is a commonly used mannitol detection method, the principle is to use liquid chromatography to separate the mannitol in the sample, and through the detector for quantitative analysis. This method is simple to operate, high accuracy, and is suitable for various types of samples.

Gas chromatography is the use of gas chromatograph in the sample of mannitol separation, and quantitative analysis by the detector. This method has high sensitivity and good separation effect, but the operation is relatively complicated and requires professional operation technology.

Infrared spectroscopy is a very convenient mannitol detection method, the principle is to detect the infrared absorption peak of mannitol in the sample for quantitative analysis. This method does not need to process the sample, the operation is simple, but the accuracy is relatively low.

Mass spectrometry is a highly sensitive mannitol detection method, the principle is to use the mass spectrometer to separate the mannitol in the sample, and through the detector for quantitative analysis. This method can not only analyze the content of mannitol quickly and accurately, but also analyze the structure of the sample, which has high analysis accuracy and sensitivity.

The detection methods of mannitol are various, each has its advantages and disadvantages, and the appropriate method can be selected for detection according to actual needs. In practical applications, we can also combine multiple methods for analysis to improve the accuracy and reliability of detection.

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