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[Chemical Knowledge]：Detection Methods and Analytical Techniques of 1,4-Butanediol

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1,4-Butanediol, as a common organic compound, its detection and analysis has attracted much attention. In industrial production, it is widely used in the synthesis of polyurethane, lubricants, solvents and other fields; in the food industry, 1,4-butanediol is also a common additive to improve the taste of food. Although it is widely used in various fields, excessive use or residues of 1,4-butanediol may cause serious harm to human health, so its detection and analysis is particularly important.

At present, the detection method and analysis technology of 1,4-butanediol have been relatively mature. One of the most common methods is gas chromatography-mass spectrometry (GC-MS). This technique enables accurate and rapid analysis of 1,4-butanediol content in a sample by separating, detecting and quantifying the target substance. By evaporating the sample into a gas, then separating it through a chromatographic column, and finally using a mass spectrometer to detect and identify the separated compounds, high sensitivity detection of 1,4-butanediol is achieved.

High performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) is also one of the commonly used methods for the determination of 1,4-butanediol. Compared with GC-MS, HPLC-MS/MS has unique advantages in liquid chromatography separation, which can more accurately separate and quantify the target substances in the sample, especially suitable for the detection of complex samples. The sample is dissolved in a solvent, then separated by a high performance liquid chromatography column, and finally detected and quantified by a mass spectrometer, so as to achieve high sensitivity and high accuracy detection of 1,4-butanediol.

In addition to the common detection methods described above, in recent years, 1,4-butanediol detection methods based on biosensing technology have also received widespread attention. Biosensing technology uses the selective recognition and response characteristics of biomolecules to specific compounds, combined with sensor technology to achieve rapid, sensitive and convenient detection of target substances. For example, a biological molecule such as an enzyme, an antibody, or a cell is used to specifically react with 1,4-butanediol, and then the change of the reaction product is detected by a sensor, thereby realizing the detection of 1,4-butanediol. This method based on biosensing technology has the advantages of simple operation and fast response, and is suitable for real-time monitoring and rapid screening of 1,4-butanediol content in samples.

In addition to industrial and food applications, 1,4-butanediol detection technology also has important applications in the field of environmental monitoring and medical diagnosis. For example, in environmental monitoring, the detection of 1,4-butanediol can help monitor pollutants in water and the atmosphere to ensure environmental safety; in medical diagnosis, the detection of 1,4-butanediol can be used for certain The diagnosis and treatment monitoring of diseases provide an important basis for medical research.

The detection method and analysis technology of 1,4-butanediol have important application value in various fields. With the continuous progress and innovation of science and technology, it is believed that in the future, more and more advanced methods and technologies will emerge to provide more comprehensive, accurate and efficient solutions for the detection and analysis of 1,4-butanediol, so as to better serve the production, life, health and safety of human beings.

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