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[Chemical Knowledge]：How to correctly measure the friability of tablets?

Read： 443 Time：7months ago Source：Transform the World with Simplicity

In the pharmaceutical industry, tablets are a common pharmaceutical dosage form. The quality and effect of tablets directly affect the patient's medication experience and treatment effect. The measurement of tablet friability is a very important link in the tablet production process. Let's introduce several aspects that need to be paid attention to when testing tablet friability.

1. to select the appropriate instrument
When performing tablet friability tests, it is very important to select the appropriate instrument. Common testing instruments include friability tester and friability tester. The friability tester is mainly used for manual testing, suitable for small batch sample testing; while the friability tester can be automatically tested, suitable for large batch sample testing. According to the actual production situation and test needs to choose the appropriate instrument to ensure the accuracy and efficiency of the test.

2. pay attention to the preparation of the sample
Before performing the tablet friability test, the sample needs to be properly prepared.

to ensure that the number of samples is sufficient, it is generally recommended to test each batch of tablets multiple times, and take the average as the final result.

to ensure that the sample storage conditions are good, avoid moisture or heat, affect the accuracy of the test results.

Before testing, samples need to be marked to avoid confusion and errors.

3. standard operation process
When testing tablet friability, it is necessary to strictly follow the standard operation process.

to put the sample into the test instrument, pre-press and test operations.

need to operate according to the instructions and operation manual of the test instrument to ensure the accuracy and repeatability of the test. At the same time, it is necessary to pay attention to recording the data during the test for subsequent data analysis and report preparation.

4. attach importance to the analysis of test results
after completing the tablet friability test, the test results need to be carefully analyzed. The

should sort out and count the data generated during the test, and calculate the average and standard deviation of the friability.

need to compare the test results with relevant quality standards and regulations to determine whether the friability of the tablets meets the requirements.

make necessary adjustments and improvements based on the test results to ensure the quality and stability of the tablets.

measurement of tablet friability is an important link in the tablet production process. We need to strictly follow the operating procedures to ensure the accuracy and reliability of the test results. At the same time, through the analysis and summary of the test results, it can help us to continuously optimize the production process, improve the quality and stability of the tablets, and provide guarantee for the patient's medication experience and treatment effect.