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[Chemical Knowledge]：The correct use of tert-butyl lithium and matters needing attention

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Tert-butyl lithium is a commonly used organic synthesis reagent, which is widely used in the field of organic synthetic chemistry. However, due to its strong activity and flammability, special attention should be paid to safety during use. The following is the correct use of tert-butyl lithium and precautions:

1 to ensure that the experimental site is well ventilated. When using tert-butyl lithium, it should be carried out in a well-ventilated laboratory with corresponding safety facilities.

2. Only operate in a dry environment. Tert-butyl lithium is very sensitive to water, so ensure that the operating environment is dry before operation and avoid contact with moisture.

3. Wear protective equipment. Wear protective clothing, goggles, and gloves when handling t-butyllithium to prevent accidental spills and injuries.

4. Slowly add. When tert-butyl lithium is added to the reaction system, it should be slowly added dropwise and the temperature should be controlled to avoid the generation of harmful gas by violent reaction.

5. Avoid prolonged contact with air. Tert-butyl lithium is easy to react with air to form a flammable and explosive mixture. It should be used as soon as possible and sealed.

6. Waste disposal. Waste after use should be properly disposed of to avoid environmental pollution.

above is the correct use of tert-butyl lithium and matters needing attention, I hope the majority of laboratory personnel can strictly abide by the operating procedures to ensure the safety of chemical experiments.

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