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[Chemical Knowledge]：What is the difference between chloroform and deuterated chloroform? How to choose correctly?

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Chloroform and deuterated chloroform are two commonly used organic compounds. They have some differences in chemical properties and application areas. This article will introduce these differences and give guidelines for the right choice. The chemical formula of

chloroform is CHCl3, while the chemical formula of deuterated chloroform is CDCl3. The only difference between them is that the hydrogen atoms in deuterated chloroform are replaced by deuterium atoms. Due to the different masses of deuterium and hydrogen, there are some differences in nuclear magnetic resonance (NMR) spectra between the two, so in NMR experiments, researchers usually choose which compound to use according to their needs.

chloroform and deuterated chloroform are also somewhat different in application. Chloroform is often used as a solvent in chemical laboratories. It has high solubility and good solubility, and can be used to dissolve inorganic salts, organic compounds and biological molecules. Deuterated chloroform is mainly used in nuclear magnetic resonance experiments. Since the NMR spectra of hydrogen and deuterium are different, the use of deuterated chloroform as a solvent can better interpret and analyze the NMR data of the sample. When

choose chloroform and deuterated chloroform, it is necessary to make a reasonable choice according to the specific experimental purpose and demand. If you need to carry out nuclear magnetic resonance experiments, you need to use deuterated chloroform as a solvent; if it is just a general chemical experiment, chloroform can meet the needs.

However, it should be noted that both chloroform and deuterated chloroform are organic solvents and have certain toxicity. When in use should follow the safety practice, do a good job of protective measures, avoid contact or inhalation of excessive compounds.

To sum up, chloroform and deuterated chloroform are two commonly used organic compounds, which are different in chemical properties, application fields and safety during use. The correct selection of the appropriate compound is critical to the outcome and safety of the experiment. It is hoped that the introduction of this article can help readers to better understand and apply these two compounds.

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