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[Chemical Knowledge]：Production method and process of butyl isobutyl acetophenone

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Butyl Isobutyl Phenyl Ketone (BIK) is an important organic chemical raw material, which is widely used in medicine, pesticide, spice and other fields. This article will introduce a manufacturing method of butyl isobutyl acetophenone.

1. raw materials and equipment

1. raw materials: acetophenone, isobutyraldehyde, butanol, sulfuric acid, sodium hydroxide.
2. Equipment: reaction kettle, condenser, water separator, stirrer, thermometer, pH meter, vacuum pump.

2. Manufacturing Steps

1. Add acetophenone and isobutyraldehyde into a reaction kettle and stir well. Sulfuric acid is then slowly added as a catalyst to control the pH between 3 and 4.
2. Heat the reaction kettle to 60-70 ° C., react for about 2 hours, then heat up to 80-90 ° C., and continue reacting for 1-2 hours. In this process, butyl isobutyl acetophenone and water are formed.
3. Separate the generated water through the water separator, and then continue to heat the reaction kettle to completely evaporate the water.
4. Add sodium hydroxide solution to the reaction kettle and adjust the pH to neutral to stop the reaction.
5. The reaction solution was washed with n-butanol, and then n-butanol was recovered by distillation to obtain crude butyl isobutyl acetophenone.
6. The crude product is subjected to vacuum distillation to collect the target boiling point fraction, which is pure butyl isobutyl acetophenone.

3. Precautions

1. Strictly control the feeding sequence and speed to avoid local overheating caused by side reactions.
2. Pay close attention to pH and temperature changes during the reaction, and adjust the amount of catalyst in time.
3. In the process of washing and distillation, the equipment should be kept closed to prevent the volatile organic solvent from polluting the environment.
4. Operators should wear protective equipment to avoid contact with toxic and harmful substances.

4. yield and purity

The yield of this manufacturing method is about 80-85%, and the purity can reach more than 98%. The yield and purity are affected by the quality of raw materials, operating conditions and other factors.

5. waste treatment and environmental protection

1. wastewater treatment: the water generated by the reaction can be used as industrial water or environmentally friendly treatment. The wastewater generated in the washing process should be treated by neutralization, precipitation, etc. to ensure that it is discharged after reaching the discharge standard.
2. Waste gas treatment: The organic waste gas produced during the reaction should be treated by adsorption, combustion, etc. to reduce environmental pollution.
3. Waste residue treatment: The waste residues produced shall be classified and treated, those that can be recycled shall be recycled, and those that cannot be recycled shall be safely buried or incinerated.

6. Safety and Protection

1. Operators need to be professionally trained to understand the nature of butyl isobutyl acetophenone and the safe operation procedures in the manufacturing process.
2. The production site should be equipped with corresponding fire-fighting facilities, such as fire extinguishers, fire hydrants, etc., and ensure their effectiveness.
3. In the process of operation, the operator should wear protective glasses, protective gloves and other protective equipment to avoid direct contact with toxic and harmful substances. Summary of

:
This paper introduces a manufacturing method of butyl isobutyl acetophenone, which is simple to operate, has a high yield, and can obtain high purity products. In the production process, we should strictly abide by the safety operation procedures, strengthen waste treatment and environmental protection work, and ensure the safety and environmental protection of the production process.

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