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[Chemical Knowledge]：Production method and process flow of tert-butyl acetophenone

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The manufacturing method
of tert-butyl acetophenone
Tert-butyl acetophenone (Tert-Butyl Acetophenone, referred to as TBA) is an important organic chemical raw material, which is widely used in medicine, pesticides, spices, plastics and other fields. This article will introduce the manufacturing method of tert-butyl acetophenone in detail, including raw material preparation, reaction process, post-treatment and precautions.

1. Raw Material Preparation

The main raw materials for the manufacture of tert-butyl acetophenone are acetophenone and isobutylene. Among them, acetophenone can be prepared by reacting benzene with acetic anhydride, and isobutylene can be obtained by naphtha cracking or propylene dimerization.

2. reaction process

The manufacturing method of tert-butyl acetophenone mainly uses alkylation reaction, that is, isobutylene and acetophenone are reacted under the action of acidic catalyst. The specific steps are as follows:

1. mix acetophenone and isobutylene in a molar ratio of 1:1.05-1.1, and add them into a reactor.
2. An appropriate amount of acidic catalyst, such as sulfuric acid, hydrofluoric acid, etc., is added to the reactor.
3. The alkylation reaction was carried out by controlling the reaction temperature at 50~70 ℃ and the reaction pressure at 0.5~1.0MPa.
4. During the reaction, sampling and analysis are required regularly, and the ratio of raw materials and reaction conditions are adjusted according to the analysis results to ensure the yield and purity of tert-butyl acetophenone.

3. post-treatment
After the end of the
reaction, a post-treatment is required to obtain a pure tert-butylacetophenone product. The specific steps are as follows:

1. the reaction solution in the reactor is poured into a separatory funnel and washed with water to remove the acidic catalyst and unreacted raw materials.
2. The organic phase was dried over anhydrous sodium sulfate and filtered to remove the drying agent.
3. Tert-butylacetophenone is separated from the organic phase by distillation, and the fraction with higher purity is collected.
Precautions for
4.

1. Pay attention to safety during operation and avoid contact with acid catalysts and high temperature and high pressure equipment.
2. raw materials acetophenone and isobutylene are flammable and explosive substances, should be stored in a cool and ventilated place, away from fire and heat sources.
3. In the manufacturing process, the reaction conditions and the ratio of raw materials should be strictly controlled to improve the yield and purity of tert-butylacetophenone.
4. Waste shall be properly disposed of to avoid environmental pollution.

In short, the manufacturing method of tert-butyl acetophenone involves raw material preparation, reaction process, post-treatment and other links, and it is necessary to strictly control the reaction conditions and operation process to ensure the quality and yield of the product. At the same time, pay attention to safety and environmental protection during operation to avoid harm to the environment and personnel.

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