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[Chemical Knowledge]：The production and manufacturing method and process of 2,2-difluoroethanol.

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Manufacturing Method
of 2,2-Difluoroethanol
1. Introduction

2,2-Difluoroethanol (DFE) is an important fluorine-containing organic compound, which is widely used in medicine, pesticides, liquid crystal materials and other fields. Due to its unique physical and chemical properties, the production method of DFE has attracted much attention. This article will introduce an effective manufacturing method in the expectation of contributing to the development of the field of raw materials for chemical production.

2. Materials and Methods

1. Material

Raw materials: chloroform, potassium fluoride, potassium hydroxide, ethylene glycol.

reagents: anhydrous sodium sulfate, saturated brine, ethyl acetate.

2. equipment

reaction kettle, stirrer, condenser, water separator, thermometer, pH meter.

3. Manufacturing Method

(1) Chloroform, potassium fluoride and potassium hydroxide are added into a reaction kettle according to a certain proportion, stirred and heated to a certain temperature, and 2,2-difluoroacetone is generated after a period of reaction.

(2) 2,2-difluoroacetone and ethylene glycol are added into a reactor, heated to a certain temperature, and the pH value is controlled, and an addition reaction is performed to generate 2,2-difluoroethanol.

(3) After completion of the reaction, the reaction mixture was cooled to room temperature, washed with saturated brine, dried over anhydrous sodium sulfate, and filtered to give a crude product. The crude product is distilled

(4) to collect the product in the specified fraction, I .e., pure 2,2-difluoroethanol.

3. Results and Discussion

1. Results

Through this manufacturing method, we successfully synthesized 2,2-difluoroethanol with high purity and high yield.

Table 1 Yield and Purity of 2,2-Difluoroethanol

| Batch | Yield (%) | Purity (%) |
|-|-|-|-|
| 1 | 85 | 98 |
| 2 | 88 | 99 |
| 3 | 90 | 99 |

2. Discuss
the effects of
(1) reaction temperature and time on yield: in the experiment, we found that the reaction temperature and time have a great influence on the yield. Appropriately increasing the reaction temperature can accelerate the reaction rate and increase the yield. However, too high temperature may lead to increased side reactions, affecting product purity. At the same time, the reaction time also needs to be properly controlled to ensure the complete progress of the reaction.

(2) The effect of raw material ratio on yield: In the experiment, we tried different raw material ratios and found that when the molar ratio of chloroform, potassium fluoride and potassium hydroxide is 1:1.2:1.5, the yield is higher. At the same time, the amount of ethylene glycol also needs to be properly controlled to ensure the smooth progress of the addition reaction.

4. conclusion

This article introduces an effective method for manufacturing 2,2-difluoroethanol. By controlling the reaction conditions, the product with high purity and satisfactory yield can be obtained. The method is easy to operate, the raw materials are easy to obtain, and has a good prospect for industrialization. It is hoped that this paper can play a certain role in promoting the development of raw materials for chemical production.

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