Current Location： Home > News > Chemical Knowledge > Production and manufacturing method and process of methyl salicylate

[Chemical Knowledge]：Production and manufacturing method and process of methyl salicylate

Read： 513 Time：12months ago Source：Transform the World with Simplicity

The manufacturing method
of methyl salicylate
methyl salicylate, also known as wintergreen oil, is an important compound widely used in the fields of chemical industry, medicine, daily chemical industry and food. Methyl salicylate has a unique wintergreen fragrance, which can be used to make fragrances and flavors, and is also an effective local analgesic and anti-inflammatory drug. The following are several main manufacturing methods of methyl salicylate in the field of chemical production raw materials.

1. esterification method:

esterification method is the most commonly used method in the production of methyl salicylate, mainly through the esterification reaction of salicylic acid and methanol in the presence of acidic catalyst to generate methyl salicylate. Commonly used acidic catalysts include sulfuric acid, phosphoric acid, p-toluenesulfonic acid, and the like. The reaction is generally carried out under normal pressure or under pressure, and the reaction temperature is determined according to the type and concentration of the catalyst and the material of the reaction equipment. After completion of the reaction, methyl salicylate and other by-products are separated by distillation or the like.

2. transesterification method:

transesterification method is mainly through the transesterification of ethyl salicylate and methanol under acidic conditions to generate methyl salicylate. The advantage of this method is that ethyl salicylate can be used as a raw material, avoiding the problems of high cost and unstable supply caused by the direct use of salicylic acid.

3. chlorination method:

chlorination method is through the reaction of salicylic acid and methanol in the presence of chlorinating agent, generating methyl salicylate and hydrochloric acid. Commonly used chlorinating agents include thionyl chloride, phosphorus trichloride, etc. This method requires timely removal of the hydrochloric acid formed during the reaction to keep the reaction going.

The above three methods have their own advantages and disadvantages. Which method to choose mainly depends on the supply of raw materials, production costs, environmental protection requirements and other factors. No matter which manufacturing method is used for

, it is necessary to strictly abide by the safety production specifications to ensure the safety and stability of the production process. At the same time, because methyl salicylate has certain toxicity and irritation, attention should be paid to the protection of operators and the protection of the environment during the production process.

In general, the manufacturing method of methyl salicylate is not complicated, but to improve production efficiency while ensuring product quality, it is necessary to continuously optimize production processes and equipment, improve production automation, reduce manual intervention, and reduce energy consumption. And waste emissions.

in order to meet the requirements of environmental protection and sustainable development, researchers are constantly exploring new and more environmentally friendly manufacturing methods of methyl salicylate. For example, some researchers use biological enzymes as catalysts for the esterification of salicylic acid and methanol. This method can be carried out under milder conditions and has a high degree of selectivity, which can reduce the generation of by-products and also avoid The environmental pollution caused by the use of chemical catalysts.

In addition, with the development of nanotechnology, researchers have also tried to use nanocatalysts to improve the production efficiency of methyl salicylate. For example, some researchers have used nano-zinc oxide as a catalyst and found that it has good catalytic activity and selectivity, and can improve the yield of methyl salicylate.

In general, the manufacturing method of methyl salicylate is constantly developing and improving. In the future, more new methods and technologies will be applied to production to improve production efficiency, reduce costs, and reduce environmental pollution. Contribute to the sustainable development of society.

Previous： Production and manufacturing method and process flow of sodium salicylate

Next： Manufacturing method and process of defoamer

News Categories