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[Chemical Knowledge]：Production method and process flow of o-tert-butyl cyclohexanol

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The manufacturing method
of o-tert-butyl cyclohexanol
o-tert-butyl cyclohexanol (O-tert-Butylcyclohexanol, referred to as OTBCH) is an important chemical raw material, widely used in fine chemicals, pharmaceuticals, pesticides and other fields. This paper will introduce an effective manufacturing method of o-t-butyl cyclohexanol.

1. raw materials and equipment

1 raw materials: cyclohexanone, tert-butyl alcohol, sodium hydroxide, water.
2. Equipment: reaction kettle, stirrer, thermometer, condenser, separatory funnel, vacuum pump, etc.

2. manufacturing steps

1. addition reaction: cyclohexanone and tert-butyl alcohol are added into a reaction kettle according to a certain proportion, heated and stirred, so that the two are fully reacted to generate o-tert-butyl cyclohexanone.
2. Catalytic hydrogenation: a certain amount of catalyst (such as nickel, palladium, etc.) is added to the reaction kettle, hydrogen is introduced, heated and stirred, so that o-t-butyl cyclohexanone is hydrogenated under the action of the catalyst to generate o-t-butyl cyclohexanol.
3. Post-treatment: After the reaction, the reaction kettle was cooled, the reaction solution was poured into a separatory funnel, washed with water, and the organic phase was separated. The organic phase was vacuumed with a vacuum pump to remove residual water to obtain crude o-t-butyl cyclohexanol.
4. Refining: Distilling the crude o-tert-butyl cyclohexanol, and collecting the product of the specified fraction to obtain o-tert-butyl cyclohexanol with higher purity.
Precautions for
3.

1. Strictly control the reaction temperature and stirring speed to ensure the smooth progress of the reaction.
2. The type and dosage of the catalyst should be selected according to the specific reaction conditions and the requirements of the target product.
3. In the post-treatment process, it is necessary to ensure that the moisture is removed to avoid affecting the quality of the product.
4. It is necessary to maintain a suitable vacuum and distillation temperature during the distillation process to obtain high-quality o-t-butyl cyclohexanol.

4. safety and environmental protection

1. in the process of operation, it is necessary to strictly abide by the laboratory safety standards, wear protective equipment, and avoid direct contact with raw materials and products.
2. The waste generated shall be classified and treated in accordance with environmental protection requirements to avoid environmental pollution.

5. yield and quality control

1. Yield improvement: By optimizing the reaction conditions (such as temperature, stirring speed, raw material ratio, etc.), the yield of o-tert-butyl cyclohexanol can be improved. In addition, the choice and amount of catalyst will also affect the yield, so experimental optimization is needed.
2. Quality control: In order to ensure product quality, it is necessary to detect the purity, moisture, color and other indicators of o-tert-butyl cyclohexanol. Qualitative and quantitative analysis of products can be carried out by analytical methods such as gas chromatography and mass spectrometry. At the same time, the intermediates of each step in the production process should also be tested to ensure the stability and reliability of the entire process.

6. Application Fields and Market Prospects

As an important chemical raw material, o-tert-butyl cyclohexanol has a wide range of applications in fine chemicals, pharmaceuticals, pesticides and other fields. For example, it can be used as an intermediate for the synthesis of certain drugs and pesticides, and can also be used to produce spices and plastic additives. With the continuous development of science and technology, the application field of o-t-butyl cyclohexanol will continue to expand, and the market prospect is broad.

summary

This article introduces an effective method for manufacturing o-tert-butyl cyclohexanol, including addition reaction, catalytic hydrogenation, post-treatment and purification. During the operation, attention should be paid to safety and environmental protection requirements, and the reaction conditions and catalyst selection should be optimized to improve the yield. Through strict control of product quality, high-quality o-tert-butyl cyclohexanol can be obtained, which provides important raw material support for fine chemicals, pharmaceuticals, pesticides and other fields.

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