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[Chemical Knowledge]：Production and manufacturing method and process flow of m-aminoacetanilide hydrochloride

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The manufacturing method
of m-aminoacetanilide hydrochloride
1. Introduction

m-aminoacetanilide hydrochloride is an important chemical production raw material, widely used in medicine, pesticides, dyes and other fields. This paper will introduce a manufacturing method of amino acetanilide hydrochloride, which has the advantages of simple operation, high yield and low cost.

2. experimental part of the

1. experimental raw materials and instrument

experimental raw materials: aniline, acetyl chloride, hydrochloric acid, sodium hydroxide, anhydrous ethanol and so on.

experimental instruments: three-necked flask, stirrer, constant pressure dropping funnel, reflux condenser, thermometer, pH meter, etc.

2. Experimental steps

(1) A certain amount of aniline and anhydrous ethanol were added into a three-necked flask. After stirring evenly, acetyl chloride was slowly added dropwise, the dropping speed was controlled, and the reaction temperature was maintained at 50-60°C.
After the dropwise addition of
(2) is completed, the reaction is stirred for 2 hours, and then the temperature is raised to 80-90 ° C., and the mixture is refluxed and dehydrated for 2 hours.

(3) is cooled to room temperature, a certain amount of hydrochloric acid is added to adjust the pH value to 4-5, and crystals of m-aminoacetanilide hydrochloride are precipitated. Filtration, washing and drying

(4) give a finished product of m-aminoacetanilide hydrochloride.

3. Experimental results and discussion

Through the experiment, we have obtained m-aminoacetanilide hydrochloride with high purity, and the yield has reached more than 85%. In the course of the experiment, we found that the reaction temperature, pH value, drop speed and other factors have a greater impact on the experimental results. Under the condition of controlling these factors, better experimental results can be obtained.

3. results and discussion

1. Structure and properties of the product

m-Aminoacetanilide hydrochloride is a white crystalline powder with a high melting point and is easily soluble in water, ethanol and other organic solvents. Its structure contains amino and carboxyl groups and other functional groups, with strong reactivity.

2. the reaction mechanism of

in the experiment, aniline and acetyl chloride acylation reaction to produce acetanilide, acetanilide and hydrochloric acid salt reaction, the generation of amino acetanilide hydrochloride. In order to ensure the smooth progress of the reaction, it is necessary to control the reaction temperature and pH value.

4. Conclusion

This paper introduces a method for the manufacture of m-aminoacetanilide hydrochloride, which has the advantages of simple operation, high yield and low cost. Through the experiment, we have obtained the high purity of m-aminoacetanilide hydrochloride product, which provides the basis for further application.

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