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[Chemical Knowledge]：Properties and Uses of POM (o-Chlorophenol)

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O-chlorophenol (POM) is an important organic chemical raw material, which is widely used in medicine, pesticide, dye, spice and other fields. This article will detail the nature and use of POM.

1. the properties of POM

POM is a colorless or slightly yellow crystalline solid with a strong pungent odor. It is insoluble in water, but soluble in alcohol, ether, benzene and other organic solvents. POM has a high melting point and boiling point of 63 ℃ and 182 ℃, respectively. In addition, POM also has the following properties:

1. Acidity: POM has a certain acidity and can react with bases to form salts.

2. Substitution reaction: The chlorine atom in POM can be replaced by other groups to generate a series of derivatives.

3. Oxidation reaction: POM can be oxidized by oxidants to generate compounds such as o-chlorobenzoquinone.

2. POM use

1. medical field

POM is an important pharmaceutical intermediates, can be used for the synthesis of antibacterial drugs, anti-inflammatory drugs, anticancer drugs and other drugs. For example, POM can react with aniline to generate o-chloroaniline, and further synthesize the anticancer drug chloramphenicol. In addition, POM can also be used to synthesize berberine, oxytetracycline and other antibacterial drugs.

2.

POM in the field of pesticides is also a common pesticide intermediate, which can be used to synthesize pesticides, fungicides, herbicides and other pesticides. For example, POM can react with formaldehyde to generate o-chlorophenol formaldehyde, and further synthesize the pesticide carbendazim. In addition, POM can also be used to synthesize the herbicide chlorsulfuron, etc.

3. Dye field

POM also has a wide range of applications in the field of dyes and can be used to synthesize a variety of dyes. For example, POM can react with aniline to generate o-chloroaniline, and further synthesize the dye Acid Red G. In addition, POM can also be used for the synthesis of direct light red 4BS, direct pink 12B and other dyes.

4. perfumery field

POM can also be used to synthesize perfumery, such as o-chlorobenzoic acid and the like. These spices are widely used in food, cosmetics and other industries to add aroma and taste to products.

In short, POM, as an important organic chemical raw material, has a wide range of applications in the fields of medicine, pesticides, dyes, spices and so on.

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