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[Chemical Knowledge]：Properties and Uses of 2,5-Diphenyloxazole

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2,5-diphenyloxazole is an important chemical raw material with unique properties and wide applications. In this paper, the properties, synthesis methods, uses and safety precautions of 2,5-diphenyl oxazole will be introduced in detail.

1. properties

2,5-diphenyloxazole is a heterocyclic compound with a special structure, the molecular formula is C13H9NO and the molecular weight is 195.22. The compound has the following properties:

1. physical properties: 2,5-diphenyloxazole is white to light yellow crystalline powder, high melting point, melting point 196-198 ℃, boiling point of 345 ℃, insoluble in water, soluble in hot ethanol, ether, acetone and other organic solvents.
2. Chemical properties: 2,5-diphenyl oxazole has good chemical stability, stable to acid and alkali, but easy to decompose at high temperature. In addition, it can also occur substitution, addition reaction.

2. synthesis method

2,5-diphenyloxazole synthesis method mainly has the following several kinds:

1. through the reaction of aniline and aldehyde preparation: under acidic conditions, aniline and aldehyde compounds condensation reaction, generate Schiff base, followed by cyclization to generate 2,5-diphenyloxazole.
2. Preparation by reduction of nitrobenzene: nitrobenzene is first reduced to aniline, and then condensed with aldehydes to form 2,5-diphenyloxazole.

3. USES

2,5-diphenyloxazole as an important chemical raw material, has a wide range of applications in medicine, pesticides, materials and other fields. The following are the main uses of 2,5-diphenyl oxazole:

1. Pharmaceutical intermediates: 2,5-diphenyl oxazole can be used as pharmaceutical intermediates for the synthesis of antibacterial drugs, anti-inflammatory drugs, anti-tumor drugs and other drugs. For example, it can be used in the synthesis of oxazole antifungal drugs such as clotrimazole, miconazole, etc.
2. Pesticide: 2,5-diphenyl oxazole has certain bactericidal and insecticidal activity and can be used as a pesticide to control crop diseases and insect pests. For example, it can be used as a fungicide to control diseases of fruit trees, vegetables and other crops.
3. Material field: 2,5-diphenyloxazole can be used as an additive in polymer materials to improve the performance of materials. For example, it can be added to the polymer as a flame retardant, antioxidant, etc., to improve the thermal stability, flame retardancy and other properties of the polymer.

4. safety production precautions

In the production and use of 2,5-diphenyloxazole, the following safety precautions need to be paid attention to:

1. Strictly abide by the operating procedures to ensure that the production and use process meets safety requirements.
2. Wear appropriate protective equipment, such as protective gloves and protective glasses, to avoid contact with skin and eyes.
3. Operate in a well-ventilated environment, avoiding inhalation of 2,5-diphenyloxazole vapors.
4. Store in a cool, dry, well-ventilated place, away from fire and heat sources.

In conclusion, 2,5-diphenyloxazole, as an important raw material for the production of chemicals, has unique properties and a wide range of uses. In the process of production and use, it is necessary to strictly abide by the safety operation procedures to ensure the safety of the production and use process.

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