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[Chemical Knowledge]：The nature and use of chlorobenzene

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P-chlorobenzyl chloride is an important raw material for chemical production and has a wide range of uses. In this article, we will discuss in detail the properties and uses of p-chlorobenzyl chloride.

1. the properties of p-chlorobenzyl chloride

p-chlorobenzyl chloride is an organic compound with a chemical formula of C7H6Cl2 and a molecular weight of 161.03. It is a colorless or yellowish transparent liquid with a strong pungent odor. Chlorobenzyl chloride is insoluble in water, but soluble in alcohol, ether, benzene and other organic solvents.

has high chemical stability to chlorobenzyl chloride, and can occur substitution reaction and addition reaction under certain conditions. In addition, it is also flammable and toxic, so special attention should be paid to safety measures during production and use.

2. of the use of chlorobenzyl chloride

1. synthetic pesticide
of chlorobenzyl chloride can be used as an important raw material for synthetic pesticides, for the production of pesticides, fungicides and herbicides. For example, through the reaction of chlorobenzyl chloride with the corresponding amine compounds, a series of highly effective and low toxic insecticides, such as chlorobenzamide, can be synthesized.

2. synthesis of pharmaceutical intermediates
can be used for the synthesis of pharmaceutical intermediates, such as antidepressants, antiepileptic drugs. Through the further reaction of chlorobenzyl chloride, a variety of compounds with biological activity can be prepared, which provides important raw material support for pharmaceutical research and development.

3. synthetic fragrances and dyes
chlorobenzyl chloride can also be used for synthetic fragrances and dyes. For example, through the reaction of chlorobenzyl chloride and aldehydes, a series of fragrant esters can be synthesized, which are widely used in the production of flavors and fragrances. In addition, p-chlorobenzyl chloride can also be used as an intermediate in the synthesis of dyes, and dyes of various colors can be prepared by further reactions.

3. production method of chlorobenzyl chloride

industrial production, usually using benzene and chloroform as raw materials, through the Friedel-Crafts acylation reaction preparation of chlorobenzyl chloride. The specific production process is as follows:

1. Benzene and chloroform are mixed according to a certain proportion, and the catalyst aluminum trichloride is added, and the reaction is carried out at a certain temperature.
2. After completion of the reaction, the mixture is cooled to room temperature, and unreacted aluminum trichloride is hydrolyzed by addition of dilute hydrochloric acid, and then neutralized to neutrality by alkali solution.
3. The p-chlorobenzyl chloride was extracted with organic solvent, and then purified by distillation to obtain the p-chlorobenzyl chloride product with high purity.
Precautions for
4.

Because p-chlorobenzyl chloride is toxic and flammable, the following matters need to be paid attention to during production and use:

1. Strictly control the exposure concentration of p-chlorobenzyl chloride to avoid inhalation or contact with skin.
2. The production site should maintain good ventilation to avoid the accumulation of harmful gases.
3. Keep away from fire and heat sources during storage and use, and avoid direct sunlight and high temperature environment.
4. The waste p-chlorobenzyl chloride shall be safely disposed in accordance with relevant laws and regulations to avoid environmental pollution.

In conclusion, as an important chemical raw material, p-chlorobenzyl chloride is widely used in the fields of pesticide, medicine, spices and dyes. In the process of production and use, it is necessary to strictly abide by relevant regulations and operating procedures to ensure safety and environmental protection.

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