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[Chemical Knowledge]：What are the upstream raw materials for ethyl acetoacetate? What do the downstream products contain?

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Ethyl acetoacetate, also known as β-ketoacid ethyl ester, is an important organic synthesis intermediate, which is widely used in the production of pharmaceuticals, pesticides, spices and other chemicals. There are many upstream and downstream related products of ethyl acetoacetate, which will be introduced separately below.

upstream associated products:

1. ethyl acetate: ethyl acetate is one of the main raw materials of ethyl acetoacetate, ethyl acetoacetate can be prepared by the esterification reaction of ethyl acetate and acetoacetic anhydride.
2. Acetoacetic anhydride: Acetoacetic anhydride is another important raw material of ethyl acetoacetate, which is prepared by the reaction of acetic anhydride with sodium acetate.

downstream associated products:

1. pharmaceutical intermediates: ethyl acetoacetate can be used for the synthesis of a variety of pharmaceutical intermediates, such as antidepressants, anti-inflammatory drugs, anti-tumor drugs. Among them, some important pharmaceutical intermediates such as ethyl propionyl acetate and propionyl chloride are derived from ethyl acetoacetate.
2. Pesticide: Ethyl acetoacetate can also be used to synthesize some pesticides, such as fungicides, insecticides, etc. For example, by the reaction of ethyl acetoacetate with phenol, a broad-spectrum fungicide, difenoconazole, can be prepared.
3. Fragrances: Ethyl acetoacetate itself has a pleasant fruity aroma, so it can also be used to modulate various fragrances. At the same time, some fragrances, such as vanillin, vanillic acid, etc., can also be prepared by the derivatives of ethyl acetoacetate.

In short, ethyl acetoacetate is an important organic synthesis intermediate, and its upstream and downstream related products are extensive, involving medicine, pesticides, spices and other fields.

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