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[Chemical Knowledge]:The magical effect of polyvinylpyrrolidone

The basic concept
of 1. polyvinylpyrrolidone
polyvinylpyrrolidone is a polymer compound, the main chain is composed of pyrrolidone rings, is a more obvious binary repeating unit. Its thermoplastic polymer, also known as poly-N-vinyl pyrrolidone, is one of the only polymers that dissolve naturally in aqueous solution at room temperature.

2. the biomedical application of polyvinylpyrrolidone

1. coating material

polyvinylpyrrolidone can be used to make coating materials, can be applied on the surface of the implant, increase its surface activity, and improve the adsorption of blood cells, support cell survival. In addition, the chemisorption properties of polyvinylpyrrolidone can be used to detect sensors and glycation end products.

2. Drug Loading Material

The drug loading capacity of polyvinylpyrrolidone is based on its hydrophobicity and the nitroxidological groups of the polymer backbone. By selecting different polyvinylpyrrolidone derivatives, materials with different molecular weights, molecular structures and drug loading properties can be obtained. The drug loading ability of polyvinylpyrrolidone is not only suitable for small molecule compounds, but also for biological macromolecules such as genes, proteins and cells.

3. Antibacterial material

Polyvinylpyrrolidone is a cationic polymer material with cationic groups on its surface. Under the condition of bacterial load, bacteria can be adsorbed on the surface by charge. Studies have found that polyvinylpyrrolidone can not only effectively kill bacteria on the surface, but also prevent the formation of plaque, and has little effect on human cells. It can be used in textiles, food packaging and other fields.

3. polyvinylpyrrolidone material preparation

method one: free radical polymerization method

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