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[Chemical Knowledge]：Effect of Enramycin -- Exploring Its Antibacterial Mechanism and Clinical Application

Read： 374 Time：18months ago Source：Transform the World with Simplicity

Enramycin, also known as cyclic esterase B, is an antibiotic produced by the Streptomyces niveus. Its structure contains an eicosylheterocyclic tetraketone and a curved dodecyl side chain. Because of its special chemical structure, enramycin has a wide range of antibacterial activity, which can effectively treat a variety of bacteria, fungi and parasites, and its effect is often better than other common antibiotics.

enramycin as a peptide antibiotic, its mechanism of action mainly includes interfering with microbial protein synthesis. Enramycin is able to cause termination of the peptide chain by binding to the site of the 16S rRNA on the 30S subunit of the bacterium. The target flora mainly covers gram-positive bacteria and some gram-negative bacteria. At the same time, enramycin also showed a significant killing effect, can specifically destroy the infected cells within the repellent.

In clinical applications, enramycin is widely used to treat a variety of infectious diseases, including skin and soft tissue infections, pneumonia, otitis media, urinary infections and gastrointestinal infections. For the treatment of some drug-resistant bacteria, enramycin also shows a good application prospect. In addition, enramycin also has the potential for local treatment, such as for local skin and soft tissue infections, which can reduce adverse reactions and possible recurrence during treatment.

Although enramycin is widely used in clinical practice, its use also requires attention to some issues. Enramycin has a long half-life (about 36 hours), so it is necessary to adjust the dose during medication. For patients during pregnancy, the use of enramycin requires caution to avoid adverse effects on the fetus.

Overall, enramycin is an important antibiotic with broad application prospects and potential clinical efficacy. Understanding the mechanism of action and application of enramycin will help us to better use and manage the drug to improve the therapeutic effect and prevent treatment-related complications.

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