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[Chemical Knowledge]：Production process and preparation method of p-hydroxyacetophenone

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Hydroxyacetophenone (HPA) is an important organic chemical intermediate, which is widely used in medicine, pesticide, dye and other fields. The process and preparation method of HPA are very important for its quality and yield. This paper will start with the chemical properties and application fields of HPA, and introduce the production process and preparation methods of HPA in detail.

1. the chemical properties of HPA

HPA has a chemical formula of C8H8O2, a molecular weight of 136.15, and is a white or yellowish crystal. It is a kind of aldoxime, which has the activity of double bond and hydroxyl group, and is easy to convert the functional group of inert bond. HPA can be synthesized by hydroxylation, formaldehyde oximation and cyanation. It has a melting point of 60-62°C and a boiling point of 284°C (760mmHg). HPA is an organic compound that is not easily soluble in water and is soluble in organic solvents such as ethanol, benzene and tetrahydrofuran.

2. the application field of HPA

HPA in the field of medicine, can be used as antiepileptic drugs, the treatment of certain vascular diseases and anti-inflammatory drugs raw materials. In the field of pesticides, HPA can be used for the preparation of microbial, plant and copper insecticides. In addition, HPA can also be used in dyes, fragrances, rubber and polymer materials.

3. HPA production process

HPA production process mainly has two kinds, one is the existing method, using nitrobenzene and ethylene as raw materials, first through the "sodium hydroxide-ethanol" method to synthesize p-hydroxyacetophenone aldehyde hydrazone, and then through the "hydrochloric acid-sodium hydroxide-light" method to reduce to p-hydroxyacetophenone; The other is a new method, using water as solvent, HPA was directly synthesized by UV irradiation of water and cationic photocatalyst to convert nitrobenzene and ethylene.

among them, the disadvantage of the traditional process technology is that it is time-consuming, each step of the reaction needs 5-6 hours, and the product crystallization temperature is low, and the product quality control is difficult. On the other hand, there are several problems in the new process technology, such as the adaptability of the electrooptic catalyst to the process is not as good as that of the cationic photocatalyst, and the reaction speed of the catalytic solution is relatively slow with too much water. There are two main methods for preparing HPA by

4.

: one is to prepare HPA by nitrobenzene and acetone. First, nitrobenzene is reduced to p-hydroxybenzene by reduction reaction, and then put into sodium hydroxide-acetone system for two-step reaction to obtain HPA; The other is prepared by nitrobenzene and methanol. First, nitrobenzene is nitrated to obtain nitrobenzaldehyde, the nitro group is then reduced to a hydroxyl group by a reduction reaction to give HPA.

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