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[Chemical Knowledge]：Production process and preparation method of diketene

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Dene is a kind of organic compound with important chemical structure, which has a wide range of applications in the field of organic synthesis. They can be used as important seasonal compounds, chemical intermediates and drug molecules. Therefore, looking for an effective production process and preparation method has become an important research topic for the synthesis of diketene.

In the production process of diketene, there are many methods to choose, such as: aldehyde condensation reaction, epoxidation reaction, oxidative addition reaction and the rearrangement reaction of hydroxyaldehyde ketone. Among them, aldehyde condensation reaction is one of the most commonly used methods for the preparation of diketene.

aldehyde condensation reaction refers to the reaction of alcohol and aldehyde under certain conditions to generate enol, and then through condensation to generate enone. The aldehyde raw material in the aldehyde condensation reaction can be various types such as aromatic aldehydes and aliphatic aldehydes. For example, the aldehyde condensation reaction can react acetaldehyde with styrene to produce phenylpropenone. Another common method for

is epoxidation. The method takes olefin as raw material, obtains epoxy compound through epoxidation reaction, and then obtains diketene through ring opening reaction. The advantages of the epoxidation reaction method are mild reaction conditions and wide application range. However, this method needs to consider the stability of the epoxy compound, and it is important to adopt suitable reaction conditions.

oxidative addition reaction is a relatively new method for the production of diketene. The method is in the presence of an oxidizing agent, the oxidation of allylic acid addition reaction, first to obtain the alkenal, and then after re-oxidation, dehydration reaction to obtain diketene. The advantage of the oxidative addition reaction is that diketene, which cannot be synthesized by other methods, can be achieved by this method. The rearrangement reaction of

hydroxyaldehydes and ketones is also a method for producing diketene. It is the use of hydroxyaldehyde ketone molecular internal methylene radical migration to the end, and finally generate a compound with a diketene structure. This method requires high purity of raw materials and precise control of reaction conditions. The intramolecular rearrangement of hydroxyaldehydes and ketones is limited to the rearrangement of hydroxyaldehydes with simple structure, while the intermolecular rearrangement is more complex.

In the preparation method of diketene, chemical synthesis method is the most common preparation method, but there are also shortcomings, such as more by-products, more synthetic steps. Therefore, some emerging technologies are widely used in the preparation of diketene.

among them, biotechnology is an emerging technology that has attracted much attention in recent years. The preparation of diketene by biotransformation has the advantages of simple operation, mild reaction conditions and environmental protection. Studies have shown that some important biotransformation products in organic synthesis can be prepared by fermentation and microbial integration.

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