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[Chemical Knowledge]：What is povidone K30? Learn about this common pharmaceutical raw material

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Povidone K30 is a milky yellow powder with good particle size and solubility. It is a pharmaceutical raw material widely used in the manufacture of oral preparations, injections, topical preparations and other drugs.

1. the properties of povidone K30

povidone K30 is an amorphous substance with a molecular weight of 39000-51000, an apparent density of 0.25-0.50g/cm³, and a viscosity of 1.4-2.4mPa · s at 20 ℃. Its water solubility increases with the increase of temperature, and it can only be soluble in water and some polar organic solvents, such as isopropanol, methanol, etc. at room temperature.

2. the use of povidone K30

povidone K30 is widely used in oral preparations, injections, external preparations and other drugs, as a thickening agent, dispersant and coating agent. Its main function is to maintain the stability of the preparation, reduce the solubility and bad taste of the drug. In addition, povidone K30 can also enhance the toughness of the capsule and improve the pharmaceutical effect.

3. Method for Producing Povidone K30

Povidone K30 is generally obtained by ethanol or isopropanol ester crosslinking polymerization. The specific production method is as follows: firstly, monomers such as methyl ethyl ketone, isopropyl ketone and glycolic acid ester are mixed, then peroxide catalyst is added, ester crosslinking is carried out in the polymerization reaction, and finally povidone K30 is obtained through glass fiber filtration, washing, drying and other steps.

4. the quality standard of povidone K30

the national standard of povidone K30 is GB2760-2014, and its main quality indicators include appearance, pH value, content, relative molecular mass, solubility and so on. Use in pharmaceutical preparations, but also to meet specific quality requirements, such as dust, heavy metals and other pollutants.

summary:

povidone K30 as a common pharmaceutical raw materials, has a wide range of uses and important role. Its nature and use need further research and development, in order to better play its application value.