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2-Pyrrolidinone (2-Pyrrolidinone)

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2-Pyrrolidinone

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2-Pyrrolidinone
2-oxopyrrolidine
1-azacyclopentan-2-one
azacyclopentan-2-one

+Expand -Stow

616-45-5

C4H7NO

85.10

2933790090

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Product Description

2-pyrrolidone is an active compound found in cabbage varieties and has anti-cancer properties. Free radical scavenging activity increased with the increase of 2-pyrrolidone dosage. The cytotoxicity of 2-pyrrolidone was found to be dose-and time-dependent, and its effect was observed by microscopy in all selected cancer cell lines. It was observed that the cytotoxic concentrations of 2-pyrrolidone to HeLa were 2.5 mg/mL, the cytotoxic concentrations to PC-3 cells were 3 mg/mL, the cytotoxic concentrations to HeLa and PC-3 cells were 1.5 mg/mL and 2 mg/mL, and the cytotoxic concentrations to PC-3 cells were 48 h, respectively. Cell viability decreased with increasing concentration of purified 2-pyrrolidone. After 24 hours of treatment with 2-pyrrolidone (IC50 concentrations of 1.5 mg/mL and 2 mg/mL, respectively, for HeLa and PC-3 cells), the morphological changes of the cells were observed. Studies have shown that 2-pyrrolidone induces apoptosis in HeLa and PC-3 cells through G0/G1 phase of cell cycle arrest [1].

Nature Description

Colorless crystals. Melting point ℃, boiling point 245℃, relative density 1.116(25/4 ℃), refractive index 1.4870. It can be miscible with water, alcohol, ether, chloroform, benzene, ethyl acetate and carbon disulfide, and is hardly soluble in petroleum ether.

1.103

250℃

25.5℃

138℃

MISCIBLE

1.486-1.488

MISCIBLE

Product Applications

Used as a solvent for plasticizer, polymerization agent, insecticide, etc.

Production method

It is usually obtained by ammoniation of γ-butyrolactone. Another preparation method uses maleic anhydride as raw material, which is obtained by hydrogenation and ammoniation, and the yield can reach 90-92.

Security

Safety instructions： S24/25: prevent contact between skin and eyes.

Hazardous material category code： R22: swallowing is harmful.

Symbols： GHS07

Storage conditions： The maximum value of the workplace is admissible concentration 100mg/m3. On-site operators should wear masks, goggles and gloves. This product is chemical inactive and has no corrosion to other metals such as carbon steel and aluminum except copper. Packed in galvanized iron drums, 50kg or 100kg per barrel. Storage and Transportation according to general chemical regulations.

Cautionary Statement： P305+P351+P338

Packaging grade： III

Signal word： Warning

Hazard Statement： H319