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[Chemical Knowledge]：Preparation of procaine hydrochloride and matters needing attention

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Procaine hydrochloride is a commonly used local anesthetic, which is also widely used in medicine and chemical industry. In the process of preparing procaine hydrochloride, some important matters need to be paid special attention to to ensure the quality and safety of the product. The following will introduce the preparation method and precautions of procaine hydrochloride.

Preparation method:
1. Raw material preparation: prepare the required raw materials, including procaine base, hydrochloric acid, solvent, etc.
2. Reaction process: Prucainbase and hydrochloric acid are added into the reaction kettle according to a certain molar ratio, and the reaction is carried out at an appropriate temperature and stirring speed.
3. Crystallization separation: The reaction product is subjected to a crystallization and separation process to obtain a finished product of procaine hydrochloride.
Precautions for
:
1. Raw material quality: Select high-quality raw materials to ensure the purity and quality of the raw materials to improve the yield and quality of the product.
2. Control of reaction conditions: Control the reaction temperature, pressure and stirring speed to avoid product quality degradation or safety hazards due to improper operation.
3. crystallization separation technology: master the technology of crystallization separation, to avoid incomplete crystallization or excessive crystallization caused by the decline in the quality of the finished product.
4. safety production: in the preparation process, we should strictly abide by the relevant safety operation procedures and take protective measures to avoid accidents.

The preparation process of procaine hydrochloride requires strict compliance with operating procedures to ensure product quality and safety. It is hoped that the preparation methods and precautions introduced in this paper can be helpful to relevant practitioners.

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